megavideolinks
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Joined: 19 Nov 2011
Posts: 12
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 Posted: Thu Dec 01, 2011 6:49 am Post subject: potential health effects of overexposure |
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Inhalation of MDI vapor and/or aerosol,
at elevated levels (above OELs), has the
potential to cause adverse health effects.
Possible effects on the respiratory system can
include the following: irritation of the nose,
throat, and lungs, causing runny nose, sore
throat, coughing, tightness in the chest, and
shortness of breath. The development of other
respiratory conditions, such as hypersensitivity
pneumonitis, also are possible, but uncommon.
Respiratory tract sensitization (i.e., the
development of asthma) is also possible
as a result of overexposure. Symptoms of
sensitization include chest tightness, shortness
of breath, coughing, and/or wheezing. These
symptoms can be delayed up to several hours
after exposure. Sensitization can be permanent,
and extreme asthmatic episodes can be life
threatening. Some MDI sensitized individuals
can experience asthmatic episodes upon
exposure to cold air, dust, or other airborne
substances, a condition known as nonspecific
bronchial hyperresponsiveness. There is
also evidence, though limited, that repeated
overexposures to MDI can lead to reduced lung
function.
MDI contact with skin can cause irritation and
sensitization effects. The signs of both are similar
and include reddening, itching, swelling, and
rash. However, in the case of sensitization, these
signs can be elicited from only a very
small exposure. Furthermore, animal tests and
other research indicate that skin contact with
isocyanates can play a role in causing isocyanate
sensitization and respiratory reaction. 3
Eye contact with MDI vapor or liquid
can cause reddening, tearing, stinging, and/or
swelling of the eyes. Conjunctivitis also
can occur.
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